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Technique
Normal Phase High Pressure Liquid Chromatography (NPC): Phenomenex
Normal phase chromatography is used for compounds that are retained too tightly by reversed phase
Normal Phase HPLC

Normal phase chromatography (NPC) is used to separate hydrophobic compounds and matrices that are retained too strongly by reversed phase and have minimal solubility in aqueous mobile phases. Normal phase stationary phases typically include polar functional groups that interact with analytes primarily via dipole-dipole and hydrogen bonding interactions.

Normal phase stationary phases typically include polar functional groups (silica, amino, and cyano) and interact with analytes primarily via dipole-dipole and hydrogen bonding interactions.

Bare silica used for Normal Phase
Brand Description:
Luna Silica Recommended for L3 USP methods
Luna CN Recommended for L10 USP methods
Luna Amino Recommended for L8 USP Method