Product Information
Phase Detail
i-Cellulose-5 Chiral LC Columns
i-Cellulose-5 Chiral LC Columns offer wide solvent flexibility for chiral LC method development

i-Cellulose-5 Chiral LC Columns

Your New First Choice Chiral Column!

The immobilization and bonding technology used within the Lux i-Cellulose-5 promotes column stability in strong organic solvents, which affords you the ability to expand your chiral separation success with more solvent systems and separation modes.

  • Wide Solvent Flexibility
  • Broad Enantioselectivity
  • Strong Solvent Compatibility

Separation Mode
Chiral
Recommended Use
Separation of enantiomers and racemic mixtures by reversed phase, normal phase, polar organic and SFC with a fully porous particle, immobilized with a polysaccharide stationary phase. This Immobilization provides additional strong organic solvent ruggedness so that DCM, DMSO and other related strong solvents can be used on column.

Achieve Greater Chiral Separation Success

Lux® i-Cellulose-5 contains achemical crosslinking between the polysaccharide and silica supports which inturn provides incredible strong solvent (THF, DCM, DMSO, MtBE, Ethyl Acetate, etc.) robustness compared to coated phases and prevents the phase from being dissolved in strong solvents.

Lower pressure, all purpose particle size for analytical LC (HPLC) or SFC methods and especially for high performance preparative LC or SFC purification work.


Dependability and Seamless Scalability

Our highest standards of quality will ensure that you are fully satisfied with each and every Lux chiral column as consistent quantitation and results come with every Lux batch and column that we manufacture. With matching selectivity, the 3 μm and 5 μm i-Cellulose-5 particle sizes allow you to scale down to increase resolution or easily scale up for preparative purification work.

Incredible consistency batch-to-batch and between particle sizes!

Conditions for all batches:

Dimension:
250 x 4.6 mm
Mobile Phase:
0.1 % Ethylamine in DCM /
0.1 % Ethylamine in Methanol (98:2)
Flow Rate:
1 mL/min
Temperature:
Ambient
Detection:
UV @ 270 nm
Sample:
Althiazide

Guaranteed Alternative to CHIRALPAK® IC® and IC-3

Conditions for both columns:

Dimension:
250 x 4.6 mm
Mobile Phase:
0.1 % Ethylamine in MtBE /
0.1 % Ethylamine in Methanol (96:4)
Flow Rate:
1 mL/min
Temperature:
Ambient
Detection:
UV @ 254 nm
Sample:
Chlorthalidone

Conditions for both columns:

Dimension:
250 x 4.6 mm
Mobile Phase:
0.1 % Ethylamine in MtBE
Flow Rate:
1 mL/min
Temperature:
Ambient
Detection:
UV @ 254 nm
Sample:
Ornidazole

Chiral Success with Lux i-Cellulose-5

Lux immobilized chiral columns offer a wide and complementary range of enantioselectivity for chiral separation projects under normal phase, reversed phase, polar ionic, or SFC separation modes. Below are examples of chiral screening using Lux i-Cellulose-5 under a variety of screening conditions.

Reversed Phase: Lux 5 µm i-Cellulose-5

Conditions for both separations:

Dimension:
250 x 4.6 mm
Part No.:
00G-4756-E0
Mobile Phase:
5 mM Ammonium Bicarbonate/
Acetonitrile (20:80)
Flow Rate:
1 mL/min
Temperature:
20 ˚C
Detection:
UV @ 254 nm
MS (Advion® Single Quad)

Normal Phase: Lux 5 µm i-Cellulose-5

Conditions:

Dimension:
250 x 4.6 mm
Part No.:
00G-4756-E0
Mobile Phase:
n-Hexane/Ethanol/DEA (80:20:0.1)
Flow Rate:
1.5 mL/min
Temperature:
27 ˚C
Detection:
UV @ 230 nm

Normal Phase: Lux 5 µm i-Cellulose-5

Conditions:

Dimension:
250 x 4.6 mm
Part No.:
00G-4756-E0
Mobile Phase:
n-Hexane/Isopropanol (80:20)
Flow Rate:
1.5 mL/min
Temperature:
20 ˚C
Detection:
UV @ 210 nm

Kavain: Lux 5 µm i-Celluose-5

Conditions:

Dimension:
250 x 4.6 mm
Part No.:
00G-4756-E0
Mobile Phase:
100% DCM (CH2CI2)
Flow Rate:
1.0 mL/min
Temperature:
25 ˚C
Detection:
UV @ 254 nm

Praziquantel: Lux 5 µm i-Celluose-5

Conditions:

Dimension:
250 x 4.6 mm
Part No.:
00G-4756-E0
Mobile Phase:
100% THF
Flow Rate:
1.0 mL/min
Temperature:
25 ˚C
Detection:
UV @ 210 nm

If you are using one of the DAICEL columns below: Guaranteed
alternative:
Phase description:
CHIRALPAK® IA® Lux i-Amylose-1 Amylose tris(3,5-dimethylphenylcarbamate)
CHIRALPAK IG® and IG-3 Lux i-Amylose-3 Amylose tris(3-chloro-5-methylphenylcarbamate)
CHIRALPAK IC® and IC-3 Lux i-Cellulose-5 Cellulose tris(3,5-dichlorophenylcarbamate)
CHIRALPAK AD®, AD-H®, AD-3, AD-RH®, and AD-3R Lux Amylose-1 Amylose tris(3,5-dimethylphenylcarbamate)
CHIRALPAK AY®, AY-H®, AY-3, AY-RH, and AY-3R Lux Amylose-2 Amylose tris(5-chloro-2-methylphenylcarbamate)
CHIRALCEL® OD®, OD-H®, OD-3, OD-RH®, and OD-3R Lux Cellulose-1 Cellulose tris(3,5-dimethylphenylcarbamate)
CHIRALCEL OZ, OZ-H®, OZ-3, OZ-RH, and OZ-3R Lux Cellulose-2 Cellulose tris(3-chloro-4-methylphenylcarbamate)
CHIRALCEL OJ®, OJ-H®, OJ-3, OJ-RH®, and OJ-3R Lux Cellulose-3 Cellulose tris(4-methylbenzoate)
CHIRALCEL OX-H, OX-3, OX-RH, and OX-3R Lux Cellulose-4 Cellulose tris(3-chloro-4-methylphenylcarbamate)