Product Information
Phase Detail
Kinetex PS C18 Core-Shell HPLC Columns
Kinetex PS C18 Core-Shell HPLC columns provide enhanced selectivity and improved peak shape for basic compounds
Kinetex PS C18 Core-Shell HPLC Columns
Improved Selectivity and Performance For Bases

The Kinetex PS C18 is a high efficiency, multi interaction selectivity C18 with a positive surface modification. The column demonstrates enhanced selectivity and improved peak shape for basic compounds under typical reversed phase conditions.

  • Compatible with All Analytical HPLC/UHPLC Systems*
  • 100 % Aqueous Mobile Phases Stable
  • C18 (USP:L1) with Improved Peak Shape for Bases

*Kinetex analytical columns are compatible with all LC system with standard LC column end-fittings threaded in 10-32. Please contact us at Phenomenex.com/chat for any questions and information about fitting compatibility and any other column internal diameters.

omega_psc18

Particle Size
2.6
Recommended Use
A multi-modal, 100 % aqueous C18 column with a positive surface modification that demonstrates unique selectivity and improved peak shape for basic compounds
Selectivity for Polar Basic Compounds

A multi-interaction, 100 % aqueous C18 column that provides great peak shape for basic compounds under low pH conditions and without sacrificing hydrophobic selectivity.

hydrophobicity
Unique Polar Basic Selectivity
The Kinetex PS C18 combines a 100 % aqueous stability C18 stationary phase, with a unique positive surface charge, and the core-shell advantage to deliver both excellent performance and reversed phase selectivity. Upgrade your traditional fully porous particle to a Kinetex PS C18 Core-Shell particle to take full polar advantage of your systems analytical capabilities. Under identical running conditions and analytes, the Kinetex PS C18 column below demonstrates unique polar selectivity with peaks associated with nortriptyline and 3-methyl 4-nitrobenzoic acid.

Basic Selectivity Comparison

Conditions for all columns:

Column:
Kinetex 2.6 µm PS C18
Kinetex 2.6 µm XB-C18
Dimension:
50 x 4.6 mm
Mobile Phase:
A: Water with 0.1 % Formic Acid
B: Acetonitrile with 0.1 % Formic Acid
Gradient:
Time (min)
0
5
6
6.1
9
 
% B
5
95
95
5
5
Flow Rate:
1.85 mL/min
Temperature:
30 °C
Injection Volume:
1 µL
Detection:
UV @ 254 nm
Samples:
1. Uracil
2. Pindolol
3. Chlorpheniramine
4. Nortriptyline
5. 3-methyl-4-nitrobenzoic Acid
6. 2-hydroxy-5-methylbenzaldehyde
7. Hexanophenone

Take Advantage of the Right Phase for the Application
While traditional alkyl C18 phases are prone to peak tailing for basic compounds due to of secondary interactions occurring at the silica surface, the surface of the Kinetex PS C18 was designed with positive charges that serve to repel basic species and deliver consistently sharper peak shape for basic compounds.

Core-Shell Comparison

Conditions for all columns:

Column:
Kinetex 2.6 µm PS C18
Core-Shell 2.6 µm C18
Dimension:
50 x 4.6 mm
Mobile Phase:
A: Water with 0.1 % Formic Acid
B: Acetonitrile with 0.1 % Formic Acid
Gradient:
Time (min)
0
2
3
3.1
5
 
% B
25
35
95
25
25
Flow Rate:
1.85 mL/min
Temperature:
Ambient
Injection Volume:
5 µL
Detection:
UV @ 254 nm
Samples:
1. Imipramine
2. Amitriptyline