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Optimizing Monoclonal Antibody Separation using bioZen™ SEC-3 Column
Accurate characterization of monoclonal antibody (mAb) aggregates has huge significance in the development of new therapeutic agents. The introduction of high efficiency UHPLC instruments offering low system dwell volume coupled with sub-2 µm particles has offered significant improvements in the resolution and characterization of aggregates and fragments. In this technical note, four monoclonal antibodies were analyzed using sub-2 µm SEC columns under optimized mobile phase conditions.
Optimizing Monoclonal Antibody Separation using bioZen™ SEC-3 Column
Accurate characterization of monoclonal antibody (mAb) aggregates has huge significance in the development of new therapeutic agents. The introduction of high efficiency UHPLC instruments offering low system dwell volume coupled with sub-2 µm particles has offered significant improvements in the resolution and characterization of aggregates and fragments. In this technical note, four monoclonal antibodies were analyzed using sub-2 µm SEC columns under optimized mobile phase conditions.
Document Type:
Technical Notes
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Separation Modes:
Size Exclusion
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